Last update
3/11/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
9.5
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
8
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Read More
Most Useful Reviews
9
Relieved lower back
1 people found this helpful
I've been taking this for a month and am thrilled with the results! My lower back discomfort has significantly reduced, and I feel much better when lifting loads.
Read More
9
Stronger joints
A good dietary supplement for strengthening joints and alleviating back pain; my husband and I have been using it from autumn to spring, and we no longer experience crunching or back pain.
Read More
9
Pain relief
Excellent! I bought it for my mother and grandmother, and their back pain has subsided.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.3
- All Researches
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
9.5
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
9
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
Read More
9
We conducted a retrospective review to uncover how vitamin D treatment impacts back pain in individuals diagnosed with adult-onset hypophosphatemic osteomalacia. In our exploration, we found that eight patients, primarily experiencing widespread musculoskeletal pain, were assessed over a span from January 2011 to December 2019.
Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.
Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.
In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.
Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.
In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
Read More
9
We conducted a double-blind study to evaluate the effectiveness of magnesium therapy for chronic low back pain that has a neuropathic component. Our research involved 80 patients, all of whom were already engaged in physical therapy and taking medications like anticonvulsants and antidepressants.
Among the participants, we divided them into two groups: one group received a placebo for six weeks, while the other group was treated with a two-week intravenous magnesium infusion followed by four weeks of oral magnesium supplements.
The results were promising for those in the magnesium group. By the end of the study, their pain intensity decreased significantly, with scores dropping from an average of 7.5 to 4.7 over six months. Additionally, we observed notable improvements in their lumbar spine mobility, suggesting that magnesium therapy could be beneficial for those suffering from this type of chronic pain.
Overall, our findings indicate that sequential intravenous and oral magnesium treatment can effectively ease pain and enhance mobility in individuals with refractory low back pain featuring a neuropathic aspect.
Among the participants, we divided them into two groups: one group received a placebo for six weeks, while the other group was treated with a two-week intravenous magnesium infusion followed by four weeks of oral magnesium supplements.
The results were promising for those in the magnesium group. By the end of the study, their pain intensity decreased significantly, with scores dropping from an average of 7.5 to 4.7 over six months. Additionally, we observed notable improvements in their lumbar spine mobility, suggesting that magnesium therapy could be beneficial for those suffering from this type of chronic pain.
Overall, our findings indicate that sequential intravenous and oral magnesium treatment can effectively ease pain and enhance mobility in individuals with refractory low back pain featuring a neuropathic aspect.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved lower back
1 people found this helpful
I've been taking this for a month and am thrilled with the results! My lower back discomfort has significantly reduced, and I feel much better when lifting loads.
Read More
9
Stronger joints
A good dietary supplement for strengthening joints and alleviating back pain; my husband and I have been using it from autumn to spring, and we no longer experience crunching or back pain.
Read More
9
Pain relief
Excellent! I bought it for my mother and grandmother, and their back pain has subsided.
Read More
9
Joint pain relief
Wonderful! This supplement works! The pain in my joints has nearly disappeared, making it easier to manage physical activity. I took one tablet twice a day and will buy more.
Read More
7.5
Less back pain
A good calcium complex! After taking it for a month, my mother’s back pain has significantly decreased.
Read More
Frequently Asked Questions
9
Relieved lower back
1 people found this helpful
I've been taking this for a month and am thrilled with the results! My lower back discomfort has significantly reduced, and I feel much better when lifting loads.
8
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
2
We examined the effectiveness of vitamin D supplementation for people dealing with chronic low back pain (CLBP). Through a systematic review of randomized controlled trials, we focused on understanding whether vitamin D could bring any relief to those suffering from this persistent discomfort.
Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.
Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.
Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
9
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
References
- Liu J, Xu D, Liu L, Huang C, Guo Z, et al. Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation. BMC Musculoskelet Disord. 2023;24:815. 10.1186/s12891-023-06896-8
- Lee TJ, Tsai RY, Ho CC, Chen CM, Li CP. Updated Meta-analysis Reveals Limited Efficacy of Vitamin D Supplementation in Chronic Low Back Pain. In Vivo. 2024;38:2955. 10.21873/invivo.13778
- Bose S, Mohanasundaram K, Rajalakshmi KV, Perumal Kumaresan A, Simon J. An Unusual Mimic of Axial Spondyloarthritis: A Case Report. Cureus. 2024;16:e61441. 10.7759/cureus.61441
- V N, Nair GG, Jose BC, Abraham A. Study on Vitamin D Levels in 30 to 40-Year-Old Females With Low Back Pain. Cureus. 2024;16:e54238. 10.7759/cureus.54238
- Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. 10.3390/medicina59122197
- Kim S, Kim SW, Lee BC, Kim DH, Sung DH. Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience. World J Clin Cases. 2023;11:7785. 10.12998/wjcc.v11.i32.7785
- Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. 10.1097/MD.0000000000032672
- Evangelatos G, Kouna K, Iliopoulos A, Fragoulis GE. Musculoskeletal Complications of Celiac Disease: A Case-Based Review. Mediterr J Rheumatol. 2023;34:86. 10.31138/mjr.34.1.86
- Dechsupa S, Yingsakmongkol W, Limthongkul W, Singhatanadgige W, Jitjumnong M, et al. Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration. Int J Mol Sci. 2023;24. 10.3390/ijms24043152
- Dadkhah P, Hashemi M, Taheri M, Alizadeh Ojoor A, Jaffari M, et al. A Comparison of Analgesic Efficacy of Triamcinolone vs Magnesium Sulfate as Adjuvants in Caudal Block in Patients with Low Back Pain: A Double-Blind Randomized Controlled Trial. Anesth Pain Med. 2024;14:e145718. 10.5812/aapm-145718
- Zhang T, Wang Y, Li R, Xin J, Zheng Z, et al. ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration. Acta Biomater. 2023;158:475. 10.1016/j.actbio.2023.01.020
- Celenlioglu AE, Sir E, Ors-Yildirim N, Yildirim AK, Ince ME, et al. Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting. J Vasc Surg Venous Lymphat Disord. 2023;11:517. 10.1016/j.jvsv.2022.09.008
- Marchesi N, Govoni S, Allegri M. Non-drug pain relievers active on non-opioid pain mechanisms. Pain Pract. 2022;22:255. 10.1111/papr.13073
- Huber D, Grafetstätter C, Proßegger J, Pichler C, Wöll E, et al. Green exercise and mg-ca-SO thermal balneotherapy for the treatment of non-specific chronic low back pain: a randomized controlled clinical trial. BMC Musculoskelet Disord. 2019;20:221. 10.1186/s12891-019-2582-4
- Yousef AA, Al-deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013;68:260. 10.1111/anae.12107
- Vormann J, Worlitschek M, Goedecke T, Silver B. Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol. 2001;15:179. PubMed
- Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. 10.1002/14651858.CD010429.pub3
- Bhardwaj A, Swe KM, Sinha NK, Osunkwo I. Treatment for osteoporosis in people with ß-thalassaemia. Cochrane Database Syst Rev. 2016;3:CD010429. 10.1002/14651858.CD010429.pub2
Data last updated:
